Fig. 7

Model depicting targeting Cox7a2 induced apoptosis of HIV-infected MDMs. Without HIV infection and without Cox7a2 knockdown, ROS induced by cells themselves cannot induce apoptosis. HIV infection alone and targeting Cox7a2 alone increased ROS production but cannot cause apoptosis. Only when ROS production reaches the threshold (dash line), do the cells undergo apoptosis. Silencing of Cox7a2 in HIV-infected macrophages results in ROS production that surpasses the threshold required to induce apoptosis