Table 1 Demographics

Gender (male)

332 (58.9%)

165 (59.3%)

167 (58.6%)

0.865

Age (mean ± SD)

64.09 ± 13.945

63.54 ± 14.258

64.64 ± 13.628

0.348

Length of stay

 ICU stay (days)

33.17 ± 31.13

39.73 ± 35.74

26.60 ± 24.02

 < 0.001

Scores

 SAPS II at study enrollment

41.41 ± 19.947

46.32 ± 20.174

36.49 ± 18.507

 < 0.001

 SOFA at ICU admission

7.11 ± 4.419

7.62 ± 4.461

6.59 ± 4.323

0.005

 Charlson at ICU admission

5.6 ± 3.01

5.61 ± 3.04

5.60 ± 2.99

0.956

Comorbidities

 Diabetes Mellitus

135 (23.7%)

62 (21.8%)

73 (25.6%)

0.278

 COPD

97 (17.0%)

42 (14.8%)

55 (19.2%)

0.147

 Past infection (3 months)

234 (41.1%)

154 (54.0%)

80 (28.0%)

 < 0.001

 Solid tumor

165 (28.9%)

79 (27.8%)

86 (30.2%)

0.518

 Hematologic malignancy

22 (3.9%)

15 (5.2%)

7 (2.4%)

0.082

 HIV

9 (1.6%)

6 (2.2%)

3 (1%)

0.313

 Cirrhosis

34 (6%)

22 (7.8%)

12 (4.2%)

0.077

 Kidney failure

245 (43%)

144 (50.6%)

101 (35.4%)

 < 0.001

 History of dialytic renal failure

66 (11.6%)

48 (16.8%)

18 (6.4%)

 < 0.001

 Renal replacement therapy

119 (20.9%)

81 (28.4%)

38 (13.4%)

 < 0.001

 Burns

0 (0%)

0 (0%)

0 (0%)

-

Known risk factors

 Candida colonization 1 site

135 (23.7%)

77 (27.0%)

58 (20.4%)

0.061

 Candida colonization (2 ≥ sties)

97 (17.0%)

65 (22.8%)

32 (11.2%)

 < 0.001

 Number of surgical abdominal interventions

1.1 ± 2.005

1.52 ± 2.32

0.68 ± 1.522

 < 0.001

 Leakage of anastomosis

76 (13.3%)

54 (19%)

22 (7.8%)

 < 0.001

 Vascular device present

529 (92.8%)

270 (94.8%)

259 (90.8%)

0.075

 TPN

297 (52.1%)

174 (61.0%)

123 (43.2%)

 < 0.001

 Mechanical ventilation

438 (76.8%)

227 (79.6%)

211 (74%)

0.112

 Solid organ transplant

23 (4%)

16 (5.6%)

7 (2.4%)

0.055

 Recent exposure to antibiotics

372 (65.3%)

215 (75.4%)

157 (55%)

 < 0.001

 Recent exposure to echinocandins

65 (11.4%)

38 (13.4%)

27 (9.4%)

0.147

 Recent exposure to azoles

62 (10.9%)

39 (13.6%)

23 (8%)

0.031

 Recent exposure to amphotericin B

6 (1.1%)

3 (1.1%)

3 (1.1%)

1

 Recent exposure to steroids

73 (13.0%)

40 (14.10%)

33 (11.6%)

0.319

 Recent exposure to other immunosuppressive drugs

49 (8.6%)

31 (10.8%)

18 (6.4%)

0.052