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Table 3 Participant characteristics and performance of OSOM® Trichomonas Rapid Test compared to reference NAAT (Aptima® Trichomonas vaginalis Assay) for T. vaginalis in pregnant women in Zambia, 2023

From: Diagnostic accuracy of an antigen-based point-of-care test versus nucleic acid amplification testing for genital trichomoniasis among pregnant women attending antenatal care facilities in Zambia

Participant characteristics

N

Prevalence (%) (95% CI)

Sensitivity (%) (95% CI)

Specificity (%) (95% CI)

Overall (symptomatic and asymptomatic participants)

 Kabuta

138a

23.2 (16.4 – 31.1)

62.5 (43.7 – 78.9)

100.0 (96.6 –100.0)

 Kafutuma

144

18.8 (12.7 – 26.1)

77.8 (57.7 – 91.4)

99.1 (95.3 – 100.0)

 Kashikishi

450a

26.4 (22.4 – 30.8)

59.7 (50.3 – 68.6)

99.7 (98.3 – 100.0)

 Nchelenge

280

19.6 (15.2 – 24.8)

72.7 (59.0 – 83.9)

99.6 (97.5 – 100.0)

 Pooled estimate

1,012a

22.3 (18.4 – 26.2)

66.4 (57.7 – 74.1)

99.6 (98.8 – 99.9)

Positive likelihood ratio = 171.2 (54.2 – 541.1)

Negative likelihood ratio = 0.34 (0.26 – 0.43)

Diagnostic odds ratio = 508 (156 – 1655)

Asymptomatic participants

 Kabuta

96a

18.8 (11.5 – 28.0)

55.6 (30.8 – 78.5)

100.0 (95.4 – 100.0)

 Kafutuma

111

17.1 (10.6 – 25.4)

73.7 (48.8 – 90.9)

98.9 (94.1 – 100.0)

 Kashikishi

371a

24.5 (20.2 – 29.2)

52.7 (42.0 – 63.3)

99.6 (98.0 – 100.0)

 Nchelenge

236

18.6 (13.9 – 24.2)

68.2 (52.4 – 81.4)

100.0 (98.1 – 100.0)

 Pooled estimate

814a

20.4 (16.7 – 24.0)

60.4 (50.3 – 69.7)

99.7 (98.7—99.9)

Positive likelihood ratio = 195.2 (46.8 – 813.8)

Negative likelihood ratio = 0.40 (0.31 – 0.51)

Diagnostic odds ratio = 491 (112 – 2159)

Symptomatic participants

 Kabuta

41a

31.7 (18.1 – 48.1)

69.2 (38.6 – 90.9)

100.0 (87.7 – 100.0)

 Kafutuma

33

24.2 (11.1 – 42.3)

100.0 (63.1 – 100.0)

100.0 (86.3 – 100.0)

 Kashikishi

78a

35.9 (25.3 – 47.6)

82.1 (63.1 – 93.9)

100.0 (92.9 – 100.0)

 Nchelenge

44

25.0 (13.2 – 40.3)

90.9 (58.7 – 99.8)

97.0 (84.2 – 99.9)

 Symptomatic

196a

30.1 (23.7 – 36.5)

83.6 (70.1 – 91.7)

99.3 (90.7—100.0)

Positive likelihood ratio = 124.0 (8.2 – 1881.8)

Negative likelihood ratio = 0.17 (0.09 – 0.32)

Diagnostic odds ratio = 749 (39 – 14,320)

  1. Symptomatic participants had at least one of the following: unusual vaginal discharge, pain during urination, itching or burning of the vulva
  2. aThe sum of symptomatic and asymptomatic cases is not equal to the overall count; one case each in Kabuta and Kashikishi was missing symptom information
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BMC Infectious Diseases

ISSN: 1471-2334

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