Table 1 Comparative table of previous studies of native valve endocarditis caused by A. aphrophilus

Our Case

58-year-old

Male

poor dental

condition

fever, fatigue, and persistent lower back pain

facet joint arthritis

all negative

vegetations on the aortic valve

and significant regurgitation

(TTE)

ABPC/SBT 3 g every 6 h and VCM

 → CTRX 2 g every 24 h

 → CPFX 400 mg every 12 h

total 6 weeks

surgical case

 → not detected

detected

Resolved

[3]

Liao, Yu

47-year-old

Male

-

fever, chills, and

decreased urine output

Roth's spot

all negative

vegetations on the mitral valve

(TEE)

CTRX and VCM

 → CPFX and TEIC

 → DAP and ERT

Duration: not mentioned

surgical case

 → not detected

detected

Resolved

[4]

Hirano, Koji

72-year-old

Female

poor dental

condition

fever

and

hematouria

ANCA-associated vasculitis

and

mycotic cerebral embolism

all negative

vegetations on the mitral valve

and significant regurgitation

(TTE)

CTRX and VCM for 4 weeks

 → CTRX for 4 more weeks

surgical case

 → not detected

detected

Resolved

[5]

Bagheri, Sina

74-year-old

Male

skin or

oral cavity

right shoulder pain, generalized weakness, chills, palpitations, and poor appetite

right shoulder abscess, complicated by septic embolization, leading to intracranial hemorrhage

positive

vegetation on the mitral valve

and moderate mitral

regurgitation

(TEE)

ABPC/SBT 3 g every 6 h

 → GM 1 mg/kg every 8 h added

 → CTRX 2 g every 24 h

for 3 more weeks

-

-

Stabilized

[6]

Daoud, Hussein

53-year-old

Male

-

confusion and word finding

difficulty, fevers, night sweats,

chills, and unintentional

weight loss

brain abscess

positive

a flail posterior leaflet with

severe regurgitation

but no clear vegetation

(TEE)

CTRX, VCM and ACV

 → CTRX for 6 weeks

-

-

Resolved

[12]

Jung, Gordon W

42-year-old

Female

poor dental

condition

reduced level of consciousness, and incontinence of urine

multiple cerebral abscesses and pulmonary abscess in the left lower lobe

all negative

but pleural fluid culture positive

mobile vegetative mass on the noncoronary cusp of the aortic valve

(TEE)

CTRX 2 g every 12 h, VCM 1 g every 12 h,

and MNZ 500 mg every 8 h

-

-

dead

[13]

Wright, P

51-year-old

Male

benign tongue

lesion

general malaise with vomiting, diarrhoea, fever, sweats and myalgia

embolic stroke and digital infarction

positive

moderate aortic regurgitation

but no obvious vegetations

(TEE)

CTRX total 6 weeks

-

-

Resolved