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Table 4 Geometric mean concentrations (GMC) and 95% confidence intervals (CI) for type-specific human papillomavirus (HPV) immunoglobulin G antibodies at three years after completion of a two-dose series of nine-valent HPV vaccine among Alaska Native children, by sex and age group at first dose

From: Immunogenicity and duration of antibodies after vaccination with a two-dose series of the nine-valent human papillomavirus vaccine among Alaska Native children: a prospective cohort study

Type

Males

[N = 79]

Females

[N = 66]

 

9–11 years old

[N = 116]

12–14 years old

[N = 29]

GMCa

(95% CI)

GMCa

(95% CI)

p-valueb

GMCa

(95% CI)

GMCa

(95% CI)

HPV 6

186

(145–240)

267

(207–344)

0.05

226

(185–276)

195

(127–300)

HPV 11

154

(123–193)

193

(157–238)

0.15

178

(149–213)

147

(108–199)

HPV 16

80

(64–100)

115

(93–143)

0.02

101

(85–119)

73

(47–113)

HPV 18

24

(18–31)

32

(25–40)

0.11

28

(23–34)

23

(15–37)

HPV 31

74

(61–91)

108

(88–132)

0.01

95

(82–110)

65

(44–97)

HPV 33

103

(80–131)

154

(119–199)

0.03

129

(105–158)

103

(68–156)

HPV 45

21

(16–27)

31

(24–40)

0.03

26

(22–32)

21

(13–33)

HPV 52

161

(132–197)

215

(170–270)

0.07

196

(166–230)

143

(96–211)

HPV 58

183

(143–234)

241

(194–299)

0.10

218

(181–263)

171

(119–245)

  1. ainternational units (IU)/mL
  2. bindependent t-test assuming unequal variances