Skip to main content

Table 2 Factors associated with mortality among people living with HIV with tuberculosis: univariate and multivariate analysis

From: Tuberculosis disease characteristics associated with mortality, severe morbidity and unsuccessful treatment in people living with HIV treated for tuberculosis – a secondary analysis of the ANRS 12300 Reflate TB2 trial

 

Univariate

Multivariate

Characteristics

N

PY

Mortality rate (100 PY)

Crude HR

95% CI

p-value

Adjusted HR

95% CI

p-value

Gender female

10

80,71

11,2

1.34

0.54–3.30

.5193

-

-

-

Age (years)

-

-

-

-

-

.5815

-

-

-

< 35

10

98.34

10.2

1

-

-

-

-

-

≥ 35

11

103.85

10.6

1.04

0.44–2.45

-

-

-

-

BMI (Kg/m2)

-

-

-

-

-

.1534

-

-

-

≥ 18

9

127.38

7.1

1

-

-

-

-

-

< 18

12

73.35

13.6

1.92

0.78–4.74

-

-

-

-

Karnofsky (%)

-

-

-

-

-

.2125

-

-

-

≥ 80

15

160.72

8.1

1

-

-

-

-

-

< 80

6

40.01

15.0

1.85

0.70–4.86

-

-

-

-

CD4 (/mm3)

-

-

-

 

-

.0421

-

-

-

≥ 100

6

104.46

5.7

1

-

-

-

-

-

< 100

15

97.27

15.4

2.66

1.03–6.88

-

-

-

-

Log10 HIV viral load

-

-

-

-

-

.3138

-

-

-

< 5 log10

3

52,42

5,7

1

-

-

-

-

-

≥ 5 log10

18

148,31

10,8

1.88

0.54–6.46

-

-

-

-

Hemoglobin (g/dL)

-

-

-

-

-

.0466

-

-

-

≥ 9

9

138.75

6.5

1

-

-

-

-

-

< 9

12

61.97

16.1

2.49

1.01–6.14

-

-

-

-

Tuberculosis anatomical site

-

-

-

-

-

.1460

-

-

-

 Pulmonary

10

138.39

7.2

1

-

-

-

-

-

 Mixed

8

37.49

18.7

2.579

0.98–6.77

-

-

-

-

 Extra pulmonary

3

24.84

8.1

1.101

0.24–5.02

-

-

-

-

Cavitation

-

-

-

-

-

.2422

-

-

.0073

 No

12

141.63

8.5

1

-

-

1

-

-

 Yes

3

16.52

18.2

2.12

0.60–7.53

-

7.92

1.74–35.94

-

Bilateral locations

-

-

-

-

-

.1509

-

-

.5475

 No

14

102.39

13.7

1

 

-

1

-

-

 Yes

7

99.8

7.0

0.51

0.20–1.27

-

0.64

0.15–2.67

-

Cavitation or bilateral location

-

-

-

-

-

.8658

-

-

-

 No

12

102.15

11.7

1

-

-

-

-

-

 Yes

9

100.04

9.0

0.92

0.37–2.27

-

-

-

-

Xpert MTB/RIF positivity level

-

-

-

-

-

.3421

-

-

-

 Negative

9

72.51

11.0

1

-

-

-

-

-

 Very low or low

5

72.36

5.5

0.50

0.15–1.66

-

-

-

-

 Medium or high

6

43.00

14.0

1.26

0.44–3.65

-

-

-

-

Smear positivity grade

-

-

-

-

-

.5460

-

-

.2963

 Negative

13

115.95

10.3

1

-

-

1

-

-

 Scanty or 1 + 

5

48.51

8.2

0.72

0.23–2.25

-

0.61

0.13–2.78

-

 2 + or 3 + 

2

39.28

5.1

0.45

0.10–2.019

-

0.15

0.01–1.61

-

TB culture and time to culture positivity

-

-

-

-

-

.5471

-

-

-

 Negative culture

11

92.19

7.6

1

-

-

-

-

-

≤ 14 days

1

32.44

0.0

0.00

-

-

-

-

-

> 14 days

8

42.94

14.0

1.84

0.61–5.48

-

-

-

-

LAM result

-

-

-

-

-

.1139

-

-

.0389

 Negative

3

70.63

4.2

1

-

-

1

-

-

 Positive

10

63.77

12.5

2.91

0.77–10.99

-

5.53

1.09–28.06

-

ART allocation

-

-

-

-

-

.6801

-

-

-

 Efavirenz

10

25.16

4.0

1

-

-

-

-

-

 Raltégravir

11

25.68

4.3

1.19

0.51–2.76

-

-

-

-

  1. N = Number of deaths; PY = Person years, HR = Hazard ratio; =; 95% CI = 95% confidence interval; ART = Antiretroviral Treatment