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Table 4 Factors associated with unsuccessful treatment among people living with HIV with tuberculosis: univariate and multivariate analysis

From: Tuberculosis disease characteristics associated with mortality, severe morbidity and unsuccessful treatment in people living with HIV treated for tuberculosis – a secondary analysis of the ANRS 12300 Reflate TB2 trial

 

Univariate

Multivariate

Characteristics

Crude OR

95% CI

p- value

Adjusted OR

95% CI

p -value

Gender female

1.15

0.75- 1.76

.5117

0.39

0.10–1.46

.1636

Age (years)

-

-

.7249

-

-

-

< 35

1

-

-

-

-

-

≥ 35

0.88

0.45–1.73

-

-

-

-

BMI (Kg/m2)

-

-

.8048

-

-

-

≥ 18

1

-

-

1

-

-

< 18

1.09

0.54–2.19

-

-

-

-

Karnofsky (%)

-

-

.4489

-

-

-

≥ 80

1

-

-

1

-

-

< 80

1.35

0.61–2.99

-

 

-

-

CD4 (/mm3)

-

-

.5139

 

-

-

≥ 100

1

-

-

1

-

-

< 100

1.25

0.63–2.45

-

-

-

-

Log10 HIV viral load

-

-

.2062

-

-

-

< 5 log10

1

-

-

1

-

-

≥ 5 log10

1.79

0.72–4.41

-

-

-

-

Hemoglobin (g/dL)

-

-

.2502

-

-

-

≥ 9

1

-

-

1

-

-

< 9

1.51

0.74–3.07

-

-

-

-

Tuberculosis anatomical site

-

-

.5045

-

-

-

 Pulmonary

1

-

-

1

-

-

 Mixed

1.60

0.70–3.64

-

-

-

-

 Extra pulmonary

1.33

0.48–3.70

-

-

-

-

Cavitation

-

-

.2176

-

-

.1174

 No

1

-

-

1

-

-

 Yes

1.91

0.68–5.35

-

3.23

0.74–14.05

-

Bilateral locations

-

-

.6524

-

-

.9821

 No

1

-

-

1

-

-

 Yes

0.84

0.41–1.72

-

1.01

0.27–3.77

-

Cavitation or bilateral location

-

-

.5616

-

-

-

 No

1

-

-

-

-

-

 Yes

1.23

0.60–2.51

-

-

-

-

Xpert MTB/RIF positivity level

-

 

.2067

-

-

-

 Negative

1

-

-

1

-

-

 Very low or low

0.56

0.23–1.38

-

-

-

-

 Medium or high

1.31

0.57–3.02

-

-

-

-

Smear positivity grade

-

-

.8208

-

-

.3812

 Negative

1

-

-

1

-

-

 Scanty or 1 + 

1.29

0.57–2.93

-

0.83

0.24–2.83

-

 2 + or 3 + 

1.10

0.44–2.76

-

0.29

0.05–1.67

-

TB culture and time to culture positivity

-

-

.8163

-

-

-

 Negative culture

1

-

-

1

-

-

≤ 14 days

1.47

0.40–5.42

-

-

-

-

> 14 days

1.16

0.56–2.42

-

-

-

-

LAM result

-

-

.1267

-

-

.0766

 Negative

1

-

-

1

-

-

 Positive

2.09

0.81–5.40

-

2.84

0.89–9.02

-

  1. OR = Odds ratio; 95% CI = 95% Confidence interval