Unexpected hypereosinophilia after Sinopharm vaccination: a case report

BMC Infectious Diseases

Table 3 Summary of reported eosinophilic events following COVID-19 vaccination

Study, Year, Country	Age, Sex	Vaccine	Onset	Clinical Manifestations	Diagnosis	Main Treatments	Outcome
Our case, 2024, Iran	66, M	BBIBP-CorV (Sinopharm)	2 months	Fever, night sweats, weight loss, non-productive cough	UE	Antibiotics Supportive care	CI
Hoxha et al. [16], 2023, Italy	48, M	BioNTech/Pfizer	5 days	Inguinal adenopathy, erythematous dermatitis	HES	Methylprednisolone Anticoagulation ASA Mepolizumab	CI
Piqueras et al. [17], 2021, Sapin	37, M	Pfizer-BioNTech	2 days	Fever, dyspnea, wheezing, chest pain, cough, palpitations, arthralgia	AEP	-	CI
Miqdadi et al. [18], 2021, Casablanca	66, M	AstraZeneca	5 h	Chest tightness, wheezing, polypnea, fever, asthenia, muscle weakness	Acute respiratory distress, and eosinophilia (25%) on CBC	Methylprednisolone	CI
Mahdi et al. [19], 2024, Qatar	Middle-aged, M	Pfizer-BioNTech	10 days	Hand clumsiness, fatigue, myalgia, non-pruritic skin rash	EGPA	Methylprednisolone Rituximab Cyclophosphamide IVIG	CI
Hwang et al. [20], 2023, Korea	71, F	Pfizer-BioNTech	After receiving	Shoulder pain, motor weakness, generalized rash	EGPA	Methylprednisolone Cyclophosphamide	CI
Nappi et al. [21], 2022, Italy	63, M	Moderna	1 day	Diplopia, headache, scotoma, impaired color vision, dry cough	EGPA	Methylprednisolone Cyclophosphamide	CI
Ramezanzade et al. [22], 2022, Iran	15, M	BBIBP-CorV (Sinopharm)	1 month	Colic-like flank pain	AAV	Prednisolone Cellcept	CI

Abbreviations: AAV ANCA-associated vasculitis, AEP Acute eosinophilic pneumonia, ANA Antinuclear antibodies, ANCA Antineutrophil cytoplasmic antibodies, ARD Acute respiratory distress, ASA Acetylsalicylic acid, CI Clinical improvement, CTX Cyclophosphamide, EGPA Eosinophilic granulomatosis with polyangiitis, HES Hypereosinophilic syndrome, IVIG Intravenous immunoglobulin, M Male, UE Unexplained eosinophilia

ISSN: 1471-2334