Operational evaluation of the deployment of Malaria/CRP Duo and Dengue Duo rapid diagnostic tests for the management of febrile illness by village malaria workers in rural Cambodia

Table 1 Febrile patient characteristics and combo-RDT results and referrals

Febrile patient characteristics	n = 2425
Sex (Male)	1103 (46%)
Age (years), median (IQR)	32 (17 to 48)
Children (< 5 years)	59 (2%)
Combo-RDT allocation
Dengue Duo	915 (38%)
Malaria/CRP Duo	1510 (62%)
Combo-RDT results
Dengue Duo	n = 915
Positive cases (NS1- and/or IgM-positive)	11 (1.2%)
NS1 + IgM	1 (0.1%)
IgM + IgG (NS1-negative)	10 (1.1%)
IgG only (NS1-negative)	8 (0.9%)
Malaria/CRP Duo	n = 1510^a
Malaria
P. falciparum	3 (0.2%)^b
P. vivax/ovale/malariae (PAN)	0 (0.0%)
CRP
Positive (> 20 mg/L)	48 (3.2%)
Positive tests referred to a health centre
Dengue Duo
Positive cases (NS1- or IgM-positive)	2/11 (18.2%)
IgG only	3/8 (37.5%)
Malaria/CRP Duo
CRP positive (> 20 mg/L)	35/48 (72.9%)

^a Some patients had only one of the tests done from the Malaria/CRP Duo (malaria only, n = 74; CRP only, n = 2)
^b Cambodian national malaria control programme (CNMCP) testing confirmed that two of these results were negative. The third did not undergo duplicate testing. No cases of P. falciparum were officially recorded/treated by the CNMCP in the study area during this time
Note: RDTs were repeated for some patients if a test was invalid or further confirmation was needed (Dengue Duo, n = 33; Malaria/CRP, n = 80). To avoid duplicate results, only the second, repeated result was used in the analysis

ISSN: 1471-2334