Table 2 Schedule of examinations during treatment and follow-up phases of the study

Clinical evaluation

Demographics, Medical History

X

Written informed consent

X

Clinical Examination

X

X

X

X

X

X

X

X

X

X

X

X

Treatment adherence

X

X

X

X

X

X

X

X

X

Concomitant treatment

X

X

X

X

X

X

X

X

X

X

Adverse events

X

X

X

X

X

X

X

X

X

X

Bacteriology

Y

Sputum smear

X

X

X

X

X

.X

X

X

X

X

X

X

Sputum culture

X

X

X

X

X

X

X

X

X

X

X

X

DST (FQ)

X

Laboratory tests

Hemoglobin/platelets count/White blood count

X

X

X

X

X

X

X

X

X

X

Serum liver enzymes

X

X

X

X

X

X

X

X

X

X

Serum creatinine (at baseline and if clinically indicated or ECG abnormalities)

X

Serum potassium (at baseline and if clinically indicated or ECG abnormalities)

X

Pregnancy test (female)

X

HIV testing

X

Other

ECG

X

Xβ

X

X

X

X

X

X

X

X

Visual acuity & BPNS(Note: for patients receiving Lzd and high-dose INH/EMB)

X

(X)

(X)

(X)

(X)

(X)

(X)

(X)

(X)

(X)

Chest X-ray

X

Disability assessment

X

X

X

Health Related Quality of Life assessment

X

X

X

X