Table 1 Clinical, microbiological, and severity characteristics of cohort

Gender n (%)

Female

6 (50)

Age n (%)

 < 1 year

10 (83)

1–5 years

1 (8)

5–10 years

0 (-)

10–18 years

1 (8)

Age (years) median (IQR)

0.6 (0.4, 0.8)

Chronic condition n (%)

No

9 (75)

Yes

3 (25)

Symptoms at presentation n (%)

Fever

8 (67)

Rash

2 (17)

Altered level of consciousness

2 (17)

Irritability

3 (25)

Seizures

1 (8)

Pain

1 (8)

Nausea/Vomiting

4 (33)

Diarrhoea

2 (17)

Respiratory distress/apnoea

4 (33)

Cough

6 (50)

Pale/cyanotic episode

2 (17)

Cold extremities

1 (8)

Skin / wound infection

0 (-)

Other

1 (8)

Primary clinical focus n (%)

Sepsis without a source

3 (25)

Lower respiratory infection

2 (17)

Upper respiratory infection

3 (25)

ENT infection/abscess

1 (8)

Other

3 (25)

Time from hospital admission to sampling (hours) median (IQR)

4.1 (2.9, 16.7)

Admission to PICU n (%)

Yes

7 (58)

Laboratory characteristics at baseline median (IQR)

Lactate [mmol/l]

1.5 (1.3, 1.8)

(N = 9)

Creatinine [µmol/l]

29 (29, 30)

(N = 11)

Bilirubin [µmol/l]

10 (6, 22)

(N = 11)

Platelets [*10³/µL]

310 (183, 406)

(N = 11)

White Cell Count [*10³/µL]

19 (11.6, 20.1)

(N = 11)

C-reactive protein [mg/L]

37.5 (29, 120)

(N = 10)

Infection Type n (%)

Definite Bacterial

6 (50)

Definite Viral

6 (50)

At least one organ dysfunction n (%)

Baseline

6 (50)

24 h

3 (25)

Organ dysfunction remote from the primary site of infection n (%)

Baseline

6 (50)

24 h

3 (25)

Any organ support n (%)

Baseline

5 (42)

24 h

3 (25)

Any Inotropes n (%)

Baseline

2 (17)

24 h

2 (17)

Multi-organ dysfunction n (%)

Baseline

5 (42)

24 h

3 (25)