Risk stratification and conservative management of women aged 25–40 years with cervical intraepithelial neoplasia grade 2(CIN2)

Table 5 Distribution of CIN3⁺ in the LEEP specimens in patients aged 25–40 years stratified by risk factors

Classification	Total (N)	Cone histopathology		P value
Classification	Total (N)	≤ CIN2	≥ CIN3	P value
Cytology: ASC-H/HSIL	45			< 0.001^*
HPV16/18	15	2(2/15) ^†	13(13/15) ^†
Other high-risk HPV	30	22(73.3%)	8(26.7%)
Cytology: ASC-US/LSIL	182			0.01^*
HPV16/18	74	50 (67.6%)	24 (32.4%)
Other high-risk HPV	108	90 (83.3%)	18 (16.7%)
Cytology: NILM + PV16/18	38	35(92.1%)	3(7.9%)

^*p < 0.05. ^†The denominator is less than 20, expressed as a fraction. NILM, negative for intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; ASC-H: atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; HR-HPV, high-risk human papillomavirus

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