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Volume 24 Supplement 1

Point-of-care Testing for Sexually Transmitted Infections: results of an independent multi-country clinic-based and clinic-utility evaluation of STI diagnostics (PRoSPeRo project)

Research

Publication of this supplement was funded by the UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), a co-sponsored programme executed by the World Health Organization (WHO) and the Government of Canada. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editors declare that they have no competing interests.

Edited by Ronald Ballard, WHO, and David Lewis, University of Sydney.

This Special Issue of BMC Infectious Diseases summarises the results from an independent multi-country (15 countries, 30 sites, over 17,000 patients) clinic-based and clinic-utility evaluation of point-of-care tests (POCT) for sexually transmitted infections (STIs) led by the World Health Organization (WHO).

Dr. Ronald Campbell Ballard provided extensive advice to the conceptual design of the PRoSPeRo Project and has been involved in this Special Issue as a Supplement Editor.

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Throughout his remarkable career, Dr. Ballard has occupied several senior positions in the field of STI control and prevention including Director of the National Reference Centre for Sexually Transmitted Diseases (STD) at the South African Institute for Medical Research (SAIMR) and Associate Professor of Medical Microbiology and Infectious Diseases at the Medical School of the University of Witwatersrand, Johannesburg, South Africa. Later, he was appointed Chief of the STD Laboratory Branch at the Centers for Disease Control and Prevention (CDC), in Atlanta GA, USA. In 2014, Dr. Ballard was subsequently appointed Associate Director for Laboratory Science, in a newly-formed Center for Global Health at CDC, in Atlanta.   

Dr. Ballard has authored more than 300 papers presented at international and local meetings and congresses on various subjects related to ocular and genital tract infections and has published over 150 publications in peer reviewed scientific journals. 

Dr. Ballard is an internationally recognized investigator and expert in STIs, microbiology and laboratory medicine.  For many years, he has continued to lead efforts to develop new diagnostic technologies for STIs, including point-of-care tests, and new interventions to improve access to STI and sexual health services. In addition, Dr. Ballard has led several impactful research projects and initiatives that aim to improve STI control and prevention as well as strengthen laboratory expertise and research capacity in several countries ranging from basic research to clinical trials.

Dr. Ballard has been a member of several WHO Expert Groups, including the WHO Committee on prevention of blindness, WHO/UNAIDS committees on syndromic management of STDs, and the WHO Director-General’s Advisory Panel on Sexually Transmitted Infections.

WHO would like to acknowledge Dr. Ballard for his outstanding contribution to international efforts to strengthen STI control and prevention at national and international levels and for his notable contribution to the development of the Special Issue of the BMC Infectious Diseases entitled “Point-of-care Testing for Sexually Transmitted Infections: results of an independent multi-country clinic-based and clinic-utility evaluation of STI diagnostics (PRoSPeRo project).”

  1. Globally, the incidence of HIV and syphilis can be reduced by the use of validated point of care tests (POCTs). As part of the WHO PRoSPeRo Network, we aimed to evaluate the performance, acceptability, and ope...

    Authors: Nigel Sherriff, Massimo Mirandola, Ronaldo Silva, Maddalena Cordioli, Alexandra Sawyer, Lorenzo Gios, Antonella Zorzi, Jorg Huber, Jaime Vera, Daniel Richardson, Mohammed Hassan-Ibrahim, Dominika Wlazly, Valeska Padovese, Christopher Barbara, Anabel Darmanin, Aaron Schembri…
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):192
  2. Sexually transmitted infections (STIs) such as syphilis and HIV remain to be a significant public health issue worldwide. Dual rapid point-of-care tests (POCTs) have shown promise for detecting antibodies to H...

    Authors: Weiping Cao, Yetunde F. Fakile, Mayur R. Shukla, Kevin Pettus, Kathryn Lupoli, Jaeyoung Hong, Allan Pillay, Ranmini Kularatne, Hicham Oumzil, Valeska Padovese, Nigel Sherriff, Isaac SSewanyana, Silver K. Vargas, Antonella Zorzi, Karel Blondeel, Igor Toskin…
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):194
  3. Sexually transmitted infections caused by Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) remain significant global health problems. The World Health Organization (WHO) has r...

    Authors: Mark Shephard, Susan Matthews, Kelly Andrewartha, Wayne Dimech, Liza Cabuang, Christopher Barbara, Xiang-Sheng Chen, Maddalena Cordioli, Amina Hançali, Ting-Ting Jiang, Ranmini Kularatne, Stephanie Meli, Etienne Muller, Hicham Oumzil, Valeska Padovese, Angela Sandri…
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):203
  4. Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections have increased globally. Asymptomatic infections represent a significant risk of long-term complications. Men who have sex with men (MSM) are d...

    Authors: Maddalena Cordioli, Lorenzo Gios, Anna Erbogasto, Massimo Mirandola, Angela Sandri, Valeska Padovese, Carlos Caceres, Silver Vargas, Karel Blondeel, Ronaldo Silva, James Kiarie, Firdavs Kurbonov, Rosanna W. Peeling, Soe Soe Thwin, Daniel Golparian, Magnus Unemo…
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):224
  5. Dual point-of-care tests (POCTs) for the simultaneous detection of antibodies to HIV and syphilis have been developed. Since community-based organisations (CBO) are effective providers of HIV and syphilis test...

    Authors: Laura Fernàndez-López, Juliana Reyes-Urueña, Laia Egea, Andrii Chernyshev, Inga Upmace, Mitja Ćosić, William Mejías, Victoria González, Karel Blondeel, Soe Soe Thwin, Lorenzo Gios, Massimo Mirandola, Rosanna Peeling, James Kiarie, Jordi Casabona and Igor Toskin
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):264
  6. In 2018, the World Health Organization commenced a multi-country validation study of the Cepheid GeneXpert for a range of molecular-based point-of-care (POC) tests in primary care settings. One study arm focus...

    Authors: Mark Shephard, Susan Matthews, Ranmini Kularatne, Kelly Andrewartha, Karel Blondeel, Christian Alvarez, Elsy Camey, Amina Hançali, Etienne Müller, Aurelie Haw, Hicham Oumzil, Daniel Golparian, Dorian E Ramirez, James Kiarie, Firdavs Kurbonov, Massimo Mirandola…
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):277
  7. International guidelines recommend routine screening for syphilis (aetiological agent: Treponema pallidum subspecies pallidum) amongst key populations and vulnerable populations using tests detecting treponemal a...

    Authors: Lorenzo Gios, Massimo Mirandola, Maddalena Cordioli, Antonella Zorzi, Nigel Sherriff, Jaime Vera, Dominika Wlazly, Mohammed Osman Hassan-Ibrahim, Valeska Padovese, Anabel Darmanin, Rosanna W. Peeling, Magnus Unemo, Karel Blondeel and Igor Toskin
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):313
  8. Southern African countries have the largest global burden of HIV and syphilis, with a high prevalence among women of reproductive age. Although antenatal screening is standard of care, syphilis screening has g...

    Authors: Ranmini Kularatne, Karel Blondeel, Margaret Kasaro, Venessa Maseko, Samuel Bosomprah, Ronaldo Silva, Maura Laverty, Firdavs Kurbonov, Massimo Mirandola and Rosanna W Peeling
    Citation: BMC Infectious Diseases 2024 24(Suppl 1):600
  9. Infection with Trichomonas vaginalis (TV) is the most prevalent curable sexually transmitted infection (STI) globally and is associated with prelabour rupture of membranes, preterm delivery, and low birthweight. ...

    Authors: Sumire Sorano, Enesia Banda Chaponda, Massimo Mirandola, Ephraim Chikwanda, Vivian Mwewa, Joyce M. Mulenga, Mike Chaponda, Ludovica Ghilardi, Emma M. Harding-Esch, Chris Smith, Mitsuaki Matsui, Daniel Chandramohan, Daniel Schröder, Daniel Golparian, Mohamed Mahmoud Ali, Karel Blondeel…
    Citation: BMC Infectious Diseases 2025 24(Suppl 1):1482

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