Articles

A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland

New vaccines with broader protection against SARS-CoV-2 are needed to reduce the risk of immune escape and provide broad and long-lasting cellular immunity. The objectives of the naNO-COVID trial were to evalu...

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Serum sST2: key biomarker in COVID-19 patients with implications for coronary artery disease

As the coronavirus disease-2019 (COVID-19) pandemic persists, post-COVID-19 syndrome (PS), characterized by symptoms like chest pain, fatigue, and palpitations, is becoming a significant medical and social iss...

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Clinical spectrum and risk factors of severe dengue infection: findings from the 2023 dengue outbreak in Bangladesh

Since the first detection of dengue in 2000, Bangladesh has been facing an increasing number of dengue patients and related deaths every year. This situation warrants the importance of quickly identifying seve...

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Lung and gut microbiota profiling in intensive care unit patients: a prospective pilot study

The gut and lung microbiomes play crucial roles in host defense and mayserve as predictive markersfor clinical outcomes in critically ill patients. Despite this, the simultaneous dynamics of lung and gut micro...

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Clinical efficacy of linezolid in the treatment of tuberculous meningitis: a retrospective analysis and literature review

Retrospective study evaluating linezolid in 99 TBM patients.

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Characterization of urinary tract infections among females at a tertiary hospital in Malawi: a retrospective study

Urinary tract infections (UTIs) are among the most common infections in females, with many experiencing at least one episode in their lifetime. About 150 million cases of UTIs occur each year. Lately, the prog...

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Overcoming HPV vaccine hesitancy: insights from a successful school-based vaccination campaign in the Saa health district of Cameroon

Vaccination against human papillomavirus (HPV) represents a critical strategy in the global effort to eradicate cervical cancer. Nonetheless, the uptake of HPV vaccination in Cameroon has been slow, resulting ...

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Higher prevalence of pulmonary tuberculosis revealed by Xpert MTB/RIF ultra among drug users in Kinshasa, Democratic Republic of Congo

The Democratic Republic of Congo (DRC) is one of the eight countries with the highest burden of tuberculosis (TB) in the world. The public health system is inadequate and the screening for TB in the key and vu...

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Central line-associated bloodstream infections (CLABSI) in critical care: understanding incidence, and risk factors in Palestine

Central line-associated bloodstream infections (CLABSIs) represent a major source of morbidity and mortality, particularly in developing countries. Central venous catheters (CVCs) are an essential part of mana...

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After the program ends: HIV testing behavior among men who have sex with men after the conclusion of a program providing regular home delivery of HIV self-testing kits

Testing for HIV continues to play a key role in prevention, especially among at-risk populations such as gay, bisexual, and other men who have sex with men (MSM). Incorporating HIV self-testing (HIVST) into te...

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Acceptability of an online peer support group as a strategy to improve antiretroviral therapy adherence among young people in Kampala district, Uganda: qualitative findings

Peer support groups may contribute to adherence and play a role in decreasing the stigma of antiretroviral therapy (ART) adherence among young people living with HIV (YPLHIV). However, peer support activities ...

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Leptin and Iinterlukin-6 relationship and influence of mortality in sepsis

Sepsis is a severe and life-threatening disease involving multiple risk factors. Leptin has been suggested to play a role in modulating the inflammatory response in sepsis and improving outcomes; however, ther...

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Correction: Comparative analysis of clinical features of brucellosis in Kashi and Guangzhou: a retrospective multicentre study

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Epidemiology of arboviruses in humans and livestock in Ethiopia: a systematic review and meta-analysis

Arbovirus infections are a global public health threat, accounting for approximately 73% of the total emerging and re-emerging human infections, where the burden is worsened in sub-Saharan Africa, including Et...

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Incidence and risk factors of surgical site infection following cesarean section: a prospective cohort study at Jimma university medical center

Surgical site infection (SSI) after cesarean section (CS) is one of the contributors for high maternal mortality and morbidity rates.

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A patient-centered view of symptoms, functional impact, and priorities in post-COVID-19 syndrome: cross-sectional results from the Québec Action Post-COVID cohort

Health services planning and mechanism-focused research would benefit from a clearer picture of symptoms, impact, and personal priorities in post-COVID-19 syndrome (PCS). This study aimed to provide estimates ...

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Economic burden of infective endocarditis in Zhejiang region from 2007 to 2016

Infective endocarditis (IE) has attracted widespread public attention. However, studies on its economic burden remain scarce.

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Evaluation of the multiplex PCR combined with capillary electrophoresis technique for detecting pathogenic bacteria and antibiotic resistance genes in bone infections

Orthopedic wound infection is a difficult problem in the clinic. Accurate and rapid microbiological test results are essential for case management, antibiotic therapy, and infection control.

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Changes in gut microbiome following anti-tuberculosis treatment: a prospective cohort from eastern China

The treatment of people with tuberculosis necessitates the administration of both broad-spectrum and narrow-spectrum antibiotics for a minimum duration of six months. Prolonged antibiotic therapy may result in...

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Sex differences in systematic screening for tuberculosis among antiretroviral therapy naïve people with HIV in Kampala, Uganda

Systematic tuberculosis (TB) screening is recommended for all people with HIV (PWH) because of its potential to improve TB outcomes through earlier diagnosis and treatment initiation. As such, systematic scree...

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Correction: Efficacy and safety of polymyxin B sulfate versus colistin sulfate in ICU patients with nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii: a multicenter, propensity score-matched, real-world cohort study

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Application of type-2 heptagonal fuzzy sets with multiple operators in multi-criteria decision-making for identifying risk factors of Zika virus

This study aims to identify and rank the key risk factors associated with the Zika virus by leveraging a novel multi-criteria decision-making (MCDM) framework based on type-2 heptagonal fuzzy sets. By integrat...

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Intensive care unit-based mortality risk model construction for severe fever with thrombocytopenia syndrome patients: a retrospective study

This study develops a predictive model to evaluate mortality risk in severe fever with thrombocytopenia syndrome (SFTS) patients in intensive care units (ICU) to improve the accuracy of prognosis and guide the...

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Academic and clinical perspectives of metagenome sequencing as a diagnostic tool for infectious disease: an interpretive phenomenological study

Effective infectious disease diagnostics (IDD) are vital for informing clinical decision-making regarding the treatment and patient management of disease and infections. In England, conventional clinical metho...

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Evaluation of QuantiFERON TB gold plus among TB household contacts in high incidence settings

Accurately identifying and categorizing individuals who are latently infected is critical for developing prevention strategies against tuberculosis (TB) disease. The QuantiFERON-TB Gold Plus (QFT-Plus), a set ...

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Vancomycin versus linezolid for treatment of staphylococcal-associated central nervous system infections

Linezolid and vancomycin are both recommended for the treatment of staphylococcal-associated central nervous system (CNS) infections. However, to date, no data are available comparing the outcomes of patients ...

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Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction

Sepsis-induced myocardial dysfunction (SIMD) is a serious sepsis complication with high mortality, yet current diagnostic and therapeutic approaches remain limited. The lack of early, specific biomarkers and e...

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Clinical presentation and treatment outcomes of extrapulmonary nontuberculous mycobacterial infections with rapid and slow growth rates in Cali, Colombia

The increasing prevalence of extrapulmonary nontuberculous mycobacterial (NTM) infections poses significant challenges in clinical management due to their inherent drug resistance, the need for prolonged antib...

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Low CD4 count was characterized in recent HIV CRF01_AE infection and it rapidly increased to reach a peak in the first year since ART initiation

Currently, most people living with HIV (PLWH) in China have a strong awareness of diagnosis and treatment in the early stage of HIV infection. Subtype-specific virological and immunological features of recentl...

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Outcomes of non-hospitalized patients with COVID-19 versus seasonal influenza during the fall-winter 2022–2023 period

The comparability of outcomes for non-hospitalized COVID-19 outpatients during the Omicron wave to outpatients with influenza remains uncertain. This study aims to compare the outcomes of non-hospitalized outp...

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Efficacy and metabolomic analysis of the pneumonia compound formulation against community-acquired pneumonia: an observational controlled before-after clinical trial

Pneumonia Compound Formulation (PCF) is a traditional Chinese medicine (TCM) formula used for the clinical treatment of novel coronavirus pneumonia. However, its efficacy and mechanism of action for community-...

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Morphological variability of Escherichia coli colonizing human wounds: a case report

Escherichia coli, known for its adaptability, can cause diverse infections. Morphological variants, such as smooth and mucoid forms, correspond to different infection capabilities and antibiotic resistance profil...

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Cefepime versus carbapenem for treating complicated urinary tract infection caused by cefoxitin-nonsusceptible ESCPM organisms: a multicenter, real-world study

This investigation aimed to compare the efficacy of cefepime and carbapenem for complicated urinary tract infection (cUTI) caused by presumptive AmpC β-lactamase-producing Enterobacter spp., Serratia marcescens, ...

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Capillary lactate as a prognostic marker in sepsis: correlation with venous lactate and prediction of outcomes

Venous lactate (VL) measured by a blood‒gas analyser is not widely available despite its importance in the management of sepsis. Capillary lactate (CL) measured via a hand-held lactate analyser is a feasible a...

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Prevalence of colistin-resistant Enterobacteriaceae isolated from clinical samples in Africa: a systematic review and meta-analysis

Antimicrobial resistance among Enterobacteriaceae poses a significant global threat, particularly in developing countries. Colistin, a critical last-resort treatment for infections caused by carbapenem-resistant ...

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Treatment completion and safety profile of once-weekly 3HP regimen for tuberculosis preventive treatment in children and adolescents: a systematic review

Children and adolescents are at increased risk of progressing from latent to active tuberculosis (TB). The 3-month, once-weekly isoniazid and rifapentine (3HP) regimen offers a shorter tuberculosis preventive ...

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The prevalence trends of Trichomonas vaginalis infection among women in Jingzhou, central of China, 2019–2023

Trichomonas vaginalis (T. vaginalis) is one of the most prevalent sexually transmitted infections globally, with significant regional variations in its prevalence. This study aimed to examine the epidemiological ...

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Late lymphocele infection with Parvimonas micra in a kidney allograft recipient

Lymphocele infection is a frequent and usually early complication following renal transplantation. We report the case of a transplanted patient with a chronic lymphocele that became infected six years after tr...

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Association between lactate-to-albumin ratio and mortality in hepatic failure: a retrospective cohort study

Liver failure has a high mortality rate, and currently, there is no convenient risk predictor. The lactate-to-albumin ratio (LAR) has emerged as a promising predictor in various critical illnesses. However, it...

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Prevalence and risk factors of high-risk HPV and cervical abnormalities in HIV-positive women in Bali, Indonesia

Women living with Human Immunodeficiency Virus (HIV) are at higher risk of cervical cancer, particularly in regions like Indonesia where cervical cancer screening programs are limited. Bali has seen a rise in ...

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Investigating Google Trends to forecast acute febrile illness outbreaks in North India reported through the Integrated Disease Surveillance Program

Acute Febrile Illness (AFI) like Malaria, Dengue, Chikungunya, and Enteric fever still remain the most common cause of seeking healthcare in low-middle-income countries and need to be constantly monitored for ...

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Bayesian spatiotemporal modelling and mapping of malaria risk among children under five years of age in Ghana

Malaria is a significant public health problem, particularly among children aged 6–59 months who bear the greatest burden of the disease. Malaria transmission is high and more pronounced in poor tropical and s...

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Seroprevalence of anti-SARS-CoV-2 IgG antibodies among children attending the pediatric hospital in Bamako, Mali (BamaCoV-Kids Study)

This study aimed to assess the seroprevalence of SARS-CoV-2 among children attending pediatric consultations in Bamako, Mali, using a rapid diagnostic test (RDT) on fingertip or venous blood samples.

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Viral suppression in the context of SARS-CoV-2 among children infected with HIV-1 monitored in five health facilities in Benin

Monitoring the effectiveness of antiretroviral treatment by measuring viral load is a strong recommendation from the WHO following the intensification of this therapy, which, if well mana...

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Correlation between peripheral lymphocyte subsets monitoring and COVID-19 pneumonia in kidney transplant recipients

In kidney transplant recipients (KTRs), immune monitoring of peripheral lymphocyte subsets (PLS) reflects the real immune status and aids in the diagnosis of the occurrence and development of infectious diseas...

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Infective endocarditis caused by Streptococcus sinensis diagnosed with next-generation sequencing: a case report and literature review

Infective endocarditis (IE) caused by Streptococcus sinensis is rare and challenging to diagnose due to the irregular use of antibiotics and the limitations of conventional diagnostic methods. Metagenomaic next-g...

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Anesthetic choice impacts mortality and bacterial clearance in a murine experimental pneumonia model

Animal models of infectious pneumonia often require the use of anesthetics, but their choice and impact on outcome is rarely discussed. This study investigates the impact of the most commonly used anesthetics ...

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Antibiotic-driven pathogen replacement events in a kidney transplant recipient with ADPKD: a case report

Retaining the native bilateral kidneys after transplantation is a common treatment for patients with end-stage autosomal dominant polycystic kidney disease. However, this strategy poses the risks of potential ...

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Risk factors for poor outcomes in patients with drug-resistant tuberculosis: a 6-year multicenter prospective study in Zhejiang, China

At present, the disease burden of drug-resistant tuberculosis (DR-TB) is still heavy in the world. In this study, we aimed to evaluate the success rate of DR-TB patients after standardized treatment and to ana...

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